Archive 1995–2023

Objectives. This paper aims to review the literature regarding the possible simultaneous use of two long-acting antipsychotics in the treatment of schizophrenia.

Selected literature review. Despite using the appropriate dose in antipsychotic treatment and continuing it for the necessary period, it happens that such treatment may be considered ineffective. In such a case, to supplement the clinical effect of antipsychotics, the addition of a second antipsychotic medication, mood stabiliser, or an antidepressant may be considered. If the inadequate response to the treatment results from poor medication adherence, the use of long-acting antipsychotic is re­commended. Some clinicians, however, try to use two long-acting antipsychotics simultaneously.

Conclusions. Sparse available data did not allow us to conclude that the simultaneous use of two long-acting antipsychotic agents significantly improves the outcome of pharmacological treatment of schizophrenia.