Archive 1995–2023

Objectives. This paper aims to summarise the existing knowledge regarding the available non-pharmacological methods of epilepsy treatment. The accurate diagnosis of patients with drug-resistant epilepsy is vital for optimising further treatment.

Literature review. In case of failure to achieve permanent seizure control with two appropriately selected and applied antiepileptic pharmacological regimens, it is recommended to consider surgical treatment. The possibility of removing the epileptic focus without causing functional deficits is evaluated (resection surgery). If the resection operation is not possible, alternative methods of treatment are palliative surgery (disconnection procedures) and neurostimulation systems. Some patients may also benefit from a ketogenic diet.

Conclusions. While a satisfactory therapeutic effect with only one of the aforementioned methods is difficult to achieve, the combined therapy is to be taken into consideration.