Archive 1995–2023
2001, volume 17, issue 3
Article
Skojarzone leczenie depresji lekami przeciwdepresyjnymi i pindololem – otwarte badanie skuteczności 14 dniowej terapii
Stanisław Pużyński1,
Łukasz Święcicki1,
Iwona Koszewska1,
Antoni Kalinowski1,
Sławomir Fornal1,
Dorota Grądzka1,
Dorota Bzinkowska1,
Magdalena Namysłowska1
1. II Klinika Psychiatryczna Instytutu Psychiatrii i Neurologii w Warszawie
Farmakoterapia w Psychiatrii i Neurologii, 2001, 3, 285-290
Summary
Twenty-four depressive patients (25 treatment modalities) were evaluated to estimate an effectiveness of combining treatment with antidepressant and pindolol. That group included also 14 treatment-resistant patients. As the results had indicated pindolol augmentation significantly reduced total scores in Hamilton Depression Rating Scale vs. baseline. That effect was not seen after 7 day of treatment. Pindolol augmentation was more effective when used with tricyclics than with serotonin selective reuptake inhibitors, but small number of patients may have an influence of that result. Combined treatment had good tolerability, although phase change from depression to mania was observed as well.