Archive 1995–2023
1998, volume 14, issue 4
Article
Inhibitory metylotransferazy katecholowej (COMT) w leczeniu choroby Parkinsona
Farmakoterapia w Psychiatrii i Neurologii, 1998, 4, 71-78
Summary
This paper presents essential patobiochemical objectives and clinical problems and results concerning the treatment of parkinsonian patients with two COMT inhibitors: entacapone and tolcapone. In November 1998, due to increased hepatotoxicity, tolcapone was withdrawn from the market.