Abstract
Therapeutic monitoring of depression is a method aiming at the optimalization of pharmacotherapy, serving to enlarge the efficacy and safety of pharmacotherapy in an individual case of illness. The application of modern monitoring techniques, such as: precise clinical assessment, determination of tricyclic antidepressant (TCA) concentration in blood or assessment of phenotype of hydroxylation enable the optimalization of therapy focused on a specific patient. On the example of therapy applied to 32 patients treated with TCA in major depression, a trial was taken up to analyse the obtained results, considering the eventual prognostic factors.