Archive 1995–2023
Ocena porównawcza metod leczenia rezydualnej schizofrenii przy użyciu neuroleptyków depot – zuclopenthixol vs flufenazyna
A comparative trial in a group of residual schizophrenics was undertaken to evaluate the clinical efficacy and relative tolerability of zuclopenthixol decanoate (Z) and fluphenazine decanoate (F), respectively. Patients were randomly allocated to receive zuclopenthixol or fluphenazine at 3- or 4-week intervals for 3 months. Forty in-patients of either sex entered the study. Positive symptoms decreased progressively in Z-group compared with partial effect in F-group. Also patients treated with zuclopenthixol showed a greater improvement as assessed on the SANS than patients treated with fluphenazine. The number of extrapyramidal side-effects observed in the patients allocated to zuclopenthixol treatment slight1y decreased over the 3-month study period contrasting with increased noted in the patients treated with fluphenazine.