Abstract
Burning mouth syndrome (BMS) is characterized by chronic burning sensations, pain, paresthesia and dryness within an oral mucosa. BMS can be a variant of neuropathic pain and may be connected with dopaminergic dysfunction of nigrostriatal system. We describe a case of patient with diagnosis of burning mouth syndrome in which a treatment with olanzapine resulted in a rapid, signifi cant improvement of symptoms. The probable mechanism of therapeutic action of olanzapine may be due to the effect of the drug on dopaminergic and histaminergic receptors and, additionally, on noradrenergic and serotonergic receptors.