Volume 23, issue 2
Review article
Pharmacokinetic interactions of valproic acid
Paweł Zatorski1, Halina Sienkiewicz-Jarosz2, Agnieszka Korkosz1, Przemysław Bieńkowski1
1. Zakład Farmakologii Instytutu Psychiatrii i Neurologii w Warszawie
2. I Klinika Neurologii Instytutu Psychiatrii i Neurologii w Warszawie
Farmakoterapia w Psychiatrii i Neurologii, 2007, 2, 83–88
Keywords: valproic acid, pharmacokinetic properties, drug-drug interactions
Abstract
Valproic acid (and its derivatives) is still widely used in the treatment of epilepsy and bipolar disorder. The drug is often administered on a long-term basis in combination with other therapeutics, and that is what generates a risk of pharmacodynamic and pharmacokinetic interactions. The aim of the present paper is to review major pharmacokinetic properties of valproic acid with special emphasis on its interactions with drugs used in internal medicine.
Address for correspondence:Przemysław Bieńkowski
Zakład Farmakologii i Fizjologii Układu Nerwowego
Instytut Psychiatrii i Neurologii
ul. Sobieskiego 9, 02-957 Warszawa
tel.: 22 – 45 82 676
e-mail:
bienkow@ipin.edu.pl