Archive 1995–2023

Serotonin syndrome is considered as a potentially fatal complication of serotoninergic drug therapy. Sometimes it can be adverse drug reaction that results from therapeutic drug use, but more often it is caused by intentional self-poisoning, or inadvertent interactions between drugs. The symptoms usually involve altered mental status, neuromuscular abnormalities, and autonomic dysfunction. Clinical manifestation of the serotonin syndrome may range from barely perceptible to lethal but in most cases there is a good prognosis when medication is discontinued.
A rewiev of case reports of serotonin syndrome published during last decade was presented and possible patomechanisms were discussed.