Abstract
Clinical assessment and neuropsychological tests measuring working memory were performed in 23 patients with depression secondary to cerebrovascular changes, before and after three-month treatment with moclobemide. Before treatment, significant global cognitive deficit and working memory disturbances were found in all investigated patients. Treatment with moclobemide resulted in an improvement of depressed symptoms and cognitive functions. The improvement of performance on neuropsychological tests, except for Stroop test B, did not show correlation with the level of improvement of depressed symptoms.