Archive 1995–2023
2005, volume 21, issue 1
Article
Refractory epilepsy and genetically determined factors
Farmakoterapia w Psychiatrii i Neurologii, 2005, 1, 25-31
Keywords: multidrug-transporter proteins, drug-metabolizing enzymes, cytochrome P-450, ion channels
Summary
Many studies indicate the role of genetic factors in the refractory epilepsy. The main directions of research enclose polymorphism of genes encoding enzymes that participate in drug metabolism, polymorphism or mutations of genes encoding multidrug-transporter proteins and drug receptors. The research of the mechanisms of refractory epilepsy development provide to better understanding and eventually to successful treatment of the disease.