Abstract
The aim of the study was to reveal the systematic structural changes in Alzheimer disease (AD) and Parkinson’s disease (PD).
8-oxo-2’-deoxyguanosine (8-oxo2dG) a marker of oxidative stress in DNA was measured in lymphocytes of AD and PD patients, and healthy controls using HPLC/EC/UV (high-pressure liquid chromatography with electrochemical and UV detections).
The content of 8-oxo2dG in lymphocytes of AD and PD patients was significantly higher than in age-matched controls. The increase of 8-oxo2dG content in the group aged 24-64 years was statistically insignificant.