Abstract
This article reviews the literature about secondary forms of restless legs syndrome induced by psychopharmacotherapy (RLS). Drug-induced forms of RLS were observed during treatment with neuroleptics, lithium, tricyclic and tetracyclic antidepressants, selective serotonin reuptake inhibitors, anticonvulsants, centrally acting antiemetic, histamine receptor H2 antagonists and after cessation of hypnotics, sedatives, anxiolytics and opioid analgesics. In addition, alcohol and caffeine were reported to increase RLS symptom s in susceptible individuals.