Abstract
Enzymatic activity of inositol monophosphatase in erythrocytes was estimated in 12 patients with schizophrenia, in 18 patients with depression in the course of affective illness and in 20 healthy control subjects. Inositol monophosphatase activity in drug-free patients with schizophrenia during exacerbation of illness was significantly higher compared to control subjects. The results obtained may suggest an importance of inositol metabolism, phosphatidyl inositol (PI) cycle or receptors acting via PI (e.g. 5HT2) in the pathogenesis of schizophrenia.